First-degree family history of cancer in women with stage I endometrial carcinoma: Prevalence and prognostic impact
Recommended Citation
Yousif A, Pudar J, Elshaikh M, Khalil-Moawad R, Elshaikh M. First-degree family history of cancer in women with stage I endometrial carcinoma: Prevalence and prognostic impact. Gynecol Oncol 2024; 190:S139-S140.
Document Type
Conference Proceeding
Publication Date
11-1-2024
Publication Title
Gynecol Oncol
Abstract
Objectives: The significance of a family history of malignancy in endometrial cancer patients has been inconsistently reported in the literature. Most cases of uterine cancer are sporadic; however, familial clustering is observed in around 5 % of cases. In our cohort, we examined the first-degree family history of cancer in women with stage I uterine endometrioid carcinoma. Methods: Our study cohort included 1741 patients. All underwent a hysterectomy and oophorectomy, and they were managed with observation or adjuvant radiotherapy alone; 701 (40 %) patients reported family history (FH) of cancer in their first-degree relatives (FDR), and 1030 reported no or unknown FH of cancer in their FDR. Descriptive statistical analysis was performed to characterize our study cohort. Results: Table 1 shows the total number of patients, 1731, among whom 701 (40 %) reported a positive family history compared to 1030 (60 %) who reported a negative family history of cancers. Both groups had similar age and race distribution. Maternal FH of cancer was reported in 50 % of patients and paternal in 34 %. Breast, colon, and endometrial cancers were most frequently reported in mothers and sisters of endometrial cancer patients, respectively. In contrast, lung, prostate, and colon cancers were the top 3 cancers in endometrial cancer patients' fathers. Cancer recurrence was slightly increased in patients with FH of cancer in their FDR (8 % vs 7 %). Conclusions: First-degree family history of cancer is common in patients with stage I endometrial cancer. Genetic counseling for patients with endometrial cancer should be considered in this population. Further research is needed to elucidate its prognostic role in endometrial cancer patients. [Formula presented]
Volume
190
First Page
S139
Last Page
S140
