Medical Therapy for Carotid and Vertebral Artery Stenosis

Document Type

Book

Publication Date

3-12-2025

Publication Title

Extracranial Carotid and Vertebral Artery Disease

Abstract

Patients with internal carotid artery or vertebral artery atherosclerotic disease should be treated with medical therapy to prevent disease progression. Antithrombotic therapies, including antiplatelet drugs, are the leading approach for preventing thrombus formation and the subsequent risk of transient ischemic attack or ischemic stroke. However, other complementary approaches to augment drug therapy are recommended, including managing cholesterol levels with statins and maintaining blood pressure control to prevent or slow ongoing vascular injury. Importantly, lifestyle modifications such as smoking cessation and increased physical activity can play a crucial role in slowing or preventing atherosclerotic disease. In this chapter, we will outline the rationale and evidence for the various therapies and treatment strategies currently in use for treating patients with carotid atherosclerosis. Additionally, the most recent clinical trials testing aggressive medical approaches for treating carotid artery stenosis will be discussed.

First Page

121

Last Page

128

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