Incidence trends among deceased liver transplant recipients in the United States, 2011-2016: A propensity score-matched study

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Conference Proceeding

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Am J Transplant


Background Donation after cardiac death (DCD) donor liver graft is a known risk factor for graft failure secondary to primary non-function (PNF) and/or diffuse cholangiopathy (DC). We aimed to study mortality and graft failure hazard ratio trends among DCD vs. donation after brain death (DBD) recipients. Methods Retrospective data of adult recipients ≥18 years from the national United Network for Organ Sharing registry 2011-2016 were analyzed. Clinically significant donor, recipient, and operative characteristics were balanced among donor groups using propensity score-matching (PSM). All-cause mortality, all-cause graft failure, graft failure due to DC and PNF were estimated using Cox proportional hazards models. Results Among a total of 29573 recipients, 1800 (6.09%) received DCD livers. Overall, PSM DCD recipients should expect worse 2-year all-cause mortality, 2-year allcause graft failure, 2-year graft failure due to DC, and 1-year graft failure due to PNF in comparison to DBD recipients (HR=1.43, 1.45, 5.24, and 3.08, respectively). PSM all-cause mortality and all-cause graft failure incidence for both DCD and DBD recipients indicate declining trends (P




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