Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.
Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone DM, Wicha MS, Kim J, and Nagrath S. Tunable thermal-sensitive polymer-graphene oxide composite for efficient capture and release of viable circulating tumor cells. Adv Mater 2016; 28(24):4891-4897.
A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.
Medical Subject Headings
Antibodies; Cell Separation; Cell Survival; Graphite; Humans; MCF-7 Cells; Microfluidics; Neoplasms; Neoplastic Cells, Circulating; Oxides; Polymers; Temperature