Title

Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Document Type

Article

Publication Date

6-1-2016

Publication Title

Adv Mater

Abstract

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

Medical Subject Headings

Antibodies; Cell Separation; Cell Survival; Graphite; Humans; MCF-7 Cells; Microfluidics; Neoplasms; Neoplastic Cells, Circulating; Oxides; Polymers; Temperature

PubMed ID

27115557

Volume

28

Issue

24

First Page

4891

Last Page

4897

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