Document Type

Conference Proceeding

Publication Date


Publication Title

Am J Obstet Gynecol


Objective: The aim of this study is to examine the efficacy of aspirin 162 mg vs 81 mg vs no aspirin in the prevention of superimposed preeclampsia among women with chronic hypertension.

Study Design: A retrospective chart review was performed at Henry Ford Health, HFH, between 2013 and 2020. Inclusion was made for all women with a diagnosis of chronic hypertension while pregnant. Three groups were identified: the ‘no aspirin’ group composed of women who were not taking aspirin during their pregnancy, and the ‘aspirin 81 mg’ and the ‘aspirin 162 mg’ groups composed of women taking aspirin 81 mg and aspirin 162 mg respectively during their pregnancies.

Results: A total of 1135 women were diagnosed with chronic hypertension: 465 women were not on aspirin prophylaxis, 459 women were on aspirin 81mg, and 211 women were on aspirin 162mg. Maternal demographics were not significantly different. Superimposed preeclampsia was diagnosed in 144 women (31.0%) in the ‘no aspirin’ group, compared to 163 (35.5%) in the ‘aspirin 81 mg’ group, and 66 (31.3%) in the ‘aspirin 162 mg’ group. There was no difference in the incidence of superimposed preeclampsia between the three groups (p=0.293). There was also no significant difference in incidence of superimposed preeclampsia when performing subgroup analysis based on chronic hypertension and concurrent: history of preeclampsia (p=0.407), BMI >30 kg/mˆ2 (p=0.894), or pregestational diabetes (p=0.0947).

Conclusion: Our results support findings in the literature which report that low dose aspirin of 81 mg is not sufficient to prevent superimposed preeclampsia among women with chronic hypertension. We here also showed that the higher dose of 162 mg is also not sufficient. This suggests a possible separate etiology for preeclampsia among this particular patient population.





First Page




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.