Sepsis in hospitalizations with short bowel syndrome: A 10-year analysis from the national inpatient sample database
Recommended Citation
Solanki S, Haq KF, Solanski D, Kichloo A, Haq KS, Patel A, Qureshi A, Khan H, Khan ZH, Ichkhanian Y, Chishti MA, Segovia M, Schiano T, Jafri S. Sepsis in hospitalizations with short bowel syndrome: A 10-year analysis from the national inpatient sample database. Am J Gastroenterol 2021; 116(SUPPL):S623-S624.
Document Type
Conference Proceeding
Publication Date
10-1-2021
Publication Title
Am J Gastroenterol
Abstract
Introduction: There appears to be a known risk of sepsis in hospitalizations with short-bowel syndrome (SBS). This is relatively well-studied in children, however, the data in adult hospitalizations with SBS complicated by sepsis is limited. Methods: We conducted a retrospective study using the national inpatient sample (NIS). We identified all patients with a primary or secondary discharge diagnosis of SBS during the years 2005 to 2014. We then identified hospitalizations complicated by sepsis. We then stratified the data into two groups: 1) SBS-sepsis and 2) SBS-no-sepsis to compare the baseline characteristics and outcomes. We also created multivariate hierarchical models to determine the predictors of mortality in the SBS hospitalizations complicated by sepsis. Results: Of 307,376 SBS hospitalizations, 53,550 hospitalizations (17.4%) were found to be complicated by sepsis. The prevalence of such complicated hospitalizations showed an upward trend from 2005 to 2014 (Figure 1). The age group 35-49 years showed the highest hospitalization rate with females were more affected than males (67.2% vs 32.8%, P<0.0001) (Table 1). Approximately 19.3% hospitalizations were emergent/urgent whereas 80.7% were elective (P<0.0001) (Table 1). Association of intestinal transplantation appeared to be higher with SBS hospitalizations complicated by sepsis as compared to those without sepsis (0.33% vs 0.22%, P<0.0001). The inpatient all-cause mortality rate was significantly higher in SBS hospitalizations complicated by sepsis than those without sepsis (8.5% vs 1.4%, P< 0.0001) (Table 1). Similarly, the mean length of stay (LOS) was significantly higher in SBS-sepsis cohort (16.1±0.4 days vs 7.7±0.1 days). In SBS-sepsis cohort, age group 18-44 years had six times higher risk of all-cause mortality than age group .5 85 years (OR 5.85; CI 3.95 - 8.66, P<0.0001). This risk appeared to decrease with increase in age. Women had higher all-cause mortality as compared to men (OR 1.18; CI 1.02 - 1.38, P=0.03), and White race was noted to have an all-cause mortality risk 1.65 times greater than as compared to other races (OR 1.65; CI 1.17 - 2.33, P=0.005). Conclusion: There was a continuous rise in SBS hospitalizations complicated by sepsis. SBS hospitalizations complicated by sepsis have a higher all-cause mortality rate and longer length of stay when compared to those without sepsis. All-cause mortality rate appeared to be higher in women and younger SBS with sepsis..
PubMed ID
Not assigned.
Volume
116
Issue
SUPPL
First Page
S623
Last Page
S624
