Ashley Budu-Aggrey
Anna Kilanowski
Maria K. Sobczyk
Suyash S. Shringarpure
Ruth Mitchell
Kadri Reis
Anu Reigo
Reedik Mägi
Mari Nelis
Nao Tanaka
Ben M. Brumpton
Laurent F. Thomas
Pol Sole-Navais
Christopher Flatley
Antonio Espuela-Ortiz
Esther Herrera-Luis
Jesus V. T Lominchar
Jette Bork-Jensen
Ingo Marenholz
Aleix Arnau-Soler
Ayoung Jeong
Katherine A. Fawcett
Hansjorg Baurecht
Elke Rodriguez
Alexessander Couto Alves
Ashish Kumar
Patrick M. Sleiman
Xiao Chang
Carolina Medina-Gomez
Chen Hu
Cheng-Jian Xu
Cancan Qi
Sarah El-Heis
Philip Titcombe
Elie Antoun
João Fadista
Carol A. Wang
Elisabeth Thiering
Baojun Wu, Henry Ford HealthFollow
Sara Kress
Dilini M. Kothalawala
Latha Kadalayil
Jiasong Duan
Hongmei Zhang
Sabelo Hadebe
Thomas Hoffmann
Eric Jorgenson
Hélène Choquet
Neil Risch
Pål Njølstad
Ole A. Andreassen
Stefan Johansson
Catarina Almqvist
Tong Gong
Vilhelmina Ullemar
Robert Karlsson
Patrik K. E Magnusson
Agnieszka Szwajda
Esteban G. Burchard
Jacob P. Thyssen
Torben Hansen
Line L. Kårhus
Thomas M. Dantoft
Alexander C. S. N Jeanrenaud
Ahla Ghauri
Andreas Arnold
Georg Homuth
Susanne Lau
Markus M. Nöthen
Norbert Hübner
Medea Imboden
Alessia Visconti
Mario Falchi
Veronique Bataille
Pirro Hysi
Natalia Ballardini
Dorret I. Boomsma
Jouke J. Hottenga
Martina Müller-Nurasyid
Tarunveer S. Ahluwalia
Jakob Stokholm
Bo Chawes
Ann-Marie M. Schoos
Ana Esplugues
Mariona Bustamante
Benjamin Raby
Syed Arshad
Chris German
Tõnu Esko
Lili A. Milani
Andres Metspalu
Chikashi Terao
Katrina Abuabara
Mari Løset
Kristian Hveem
Bo Jacobsson
Maria Pino-Yanes
David P. Strachan
Niels Grarup
Allan Linneberg
Young-Ae Lee
Nicole Probst-Hensch
Stephan Weidinger
Marjo-Riitta Jarvelin
Erik Melén
Hakon Hakonarson
Alan D. Irvine
Deborah Jarvis
Tamar Nijsten
Liesbeth Duijts
Judith M. Vonk
Gerard H. Koppelmann
Keith M. Godfrey
Sheila J. Barton
Bjarke Feenstra
Craig E. Pennell
Peter D. Sly
Patrick G. Holt
Keoki L. Williams, Henry Ford HealthFollow
Hans Bisgaard
Klaus Bønnelykke
John Curtin
Angela Simpson
Clare Murray
Tamara Schikowski
Supinda Bunyavanich
Scott T. Weiss
John W. Holloway
Josine L. Min
Sara J. Brown
Marie Standl
Lavinia Paternoster

Document Type


Publication Date


Publication Title

Nat Commun


Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.

Medical Subject Headings

Humans; Genome-Wide Association Study; Dermatitis, Atopic; Genetic Predisposition to Disease; Hispanic or Latino; Black People; Polymorphism, Single Nucleotide

PubMed ID






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