Identification of Risk Factors Associated With Postoperative Acute Kidney Injury After Esophagectomy for Esophageal Cancer.
Konda P, Ai D, Guerra CE, Rodriguez-Restrepo A, Mehran RJ, Rice D, Hofstetter W, Heir J, Kwater P, Gottumukkala V, Hernandez M, Cata JP. Identification of Risk Factors Associated With Postoperative Acute Kidney Injury After Esophagectomy for Esophageal Cancer.. Journal of cardiothoracic and vascular anesthesia 2017; 31(2):474-481.
Journal of cardiothoracic and vascular anesthesia
OBJECTIVE: To identify risks factors associated with acute kidney injury (AKI) after esophageal cancer surgery.
DESIGN: This was a retrospective study.
SETTING: Single academic center.
PARTICIPANTS: Subjects with non-metastatic esophageal cancer. Patients were excluded if they were younger than 18 years and had missing data.
MEASUREMENTS AND MAIN RESULTS: Primary outcome of the study was AKI according to AKI Network criteria. Demographic and perioperative variables were compared in patients with and without AKI. A multivariate Cox proportional model was used to assess the association between perioperative variables and AKI; p
CONCLUSIONS: In support of previous reports in the literature, the authors found that AKI was not an uncommon complication after esophageal surgery. Obesity, cardiovascular comorbidities, and high preoperative concentrations were predictors of AKI. Dexamethasone administration during surgery appeared to have a protective effect. This finding opens an opportunity to further study in a randomized controlled trial the efficacy of dexamethasone in the prevention of AKI.
Medical Subject Headings
Acute Kidney Injury; Aged; Cohort Studies; Creatinine; Esophageal Neoplasms; Esophagectomy; Female; Humans; Male; Middle Aged; Obesity; Postoperative Complications; Retrospective Studies; Risk Factors