Sex Differences in Cardiorespiratory Fitness and All-Cause Mortality: The Henry Ford ExercIse Testing (FIT) Project
Al-Mallah MH, Juraschek SP, Whelton S, Dardari ZA, Ehrman JK, Michos ED, Blumenthal RS, Nasir K, Qureshi WT, Brawner CA, Keteyian SJ, Blaha MJ. Sex differences in cardiorespiratory fitness and all-cause mortality: The henry ford exercise testing (fit) project. Mayo Clin Proc. Jun 2016;91(6):755-762.
Mayo Clinic proceedings. Mayo Clinic
OBJECTIVE: To determine whether sex modifies the relationship between fitness and mortality.
PATIENTS AND METHODS: We included 57,284 patients without coronary artery disease or heart failure who completed a routine treadmill exercise test between 1991 and 2009. We determined metabolic equivalent tasks (METs) and linked patient records with mortality data via the Social Security Death Index. Multivariable Cox regression was used to determine the association between sex, fitness, and all-cause mortality.
RESULTS: There were 29,470 men (51.4%) and 27,814 women (48.6%) with mean ages of 53 and 54 years, respectively. Overall, men achieved 1.7 METs higher than women (P
CONCLUSION: Although men demonstrated 1.7 METs higher than women, their survival was equivalent to that of women demonstrating 2.6 METs lower. Furthermore, higher MET values were associated with lower mortality for both men and women across the range of MET values. These findings are useful for tailoring prognostic information and lifestyle guidance to men and women undergoing stress testing.
Medical Subject Headings
Cardiorespiratory Fitness; Cause of Death; Coronary Artery Disease; Exercise Test; Female; Heart Failure; Humans; Male; Metabolic Equivalent; Michigan; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Sex Distribution