Effect of Preoperative Albumin Levels on Outcomes in Patients Undergoing Left Ventricular Device Implantation
Go PH, Hodari A, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G, Morgan JA. Effect of preoperative albumin levels on outcomes in patients undergoing left ventricular device implantation. ASAIO J. 2015;61(6):734-7.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Hypoalbuminemia is a well-known predictor of morbidity and mortality in cardiac surgery. Our aim was to establish the impact of serum albumin on outcomes after left ventricular assist device (LVAD) implantation. This was a single-institution retrospective review, including all patients who underwent LVAD implantation between March 2006 and June 2014. Two hundred patients were included in the analysis. Mean serum albumin was 3.27 ± 0.47 g/dl, with 7% in the low albumin group (3.5 mg/dl). Lower albumin was associated with a significant increase in postoperative renal failure (42.9 vs. 16.5 vs. 17.3%; p = 0.05) and prolonged hospitalization (median 28.5 vs. 16 vs. 15.5 days; p = 0.008). Six month, 1 year, and 5 year survival was 79%, 79%, and 49% with low, 84%, 78%, and 51% with mid-range, and 94%, 88%, and 60% with normal albumin, respectively (p = 0.22). Preoperative hypoalbuminemia is associated with postoperative acute renal failure (ARF) and prolonged hospitalization after LVAD implantation, with no effect on overall survival. Hypoalbuminemia is most likely a marker of advanced disease and should not, in itself, be considered a contraindication to LVAD candidacy.
Medical Subject Headings
Adolescent; Adult; Aged; Female; Heart Failure; Heart-Assist Devices; Humans; Hypoalbuminemia; Insulin, Long-Acting; Insulin, Regular, Human; Male; Middle Aged; Preoperative Period; Retrospective Studies; Serum Albumin; Serum Albumin, Human; Treatment Outcome; Young Adult