Prognostic Usefulness of Planar
Agostini D, Ananthasubramaniam K, Chandna H, Friberg L, Hudnut A, Koren M, Miyamoto MI, Senior R, Shah M, Travin MI, Dahl JV, Chen K, and Levy WC. Prognostic Usefulness of Planar (123)I-MIBG Scintigraphic Images of Myocardial Sympathetic Innervation in Congestive Heart Failure: Follow-Up Data from ADMIRE-HF. J Nucl Cardiol 2019.
Journal of nuclear cardiology
BACKGROUND: To evaluate whether planar (123)I-MIBG myocardial scintigraphy predicts risk of death in heart failure (HF) patients up to 5 years after imaging. METHODS AND RESULTS: Subjects from ADMIRE-HF were followed for approximately 5 years after imaging (964 subjects, median follow-up 62.7 months). Subjects were stratified according to the heart/mediastinum (H/M) ratio (< 1.60 vs >/= 1.60) on planar (123)I-MIBG scintigraphic images obtained at baseline in ADMIRE-HF. Cox proportional hazards models and Kaplan-Meier analyses were used to evaluate time to death, cardiac death, or arrhythmic events for subjects stratified by H/M ratio, baseline left ventricular ejection fraction (LVEF: < 25% and 25 to /= 1.60, respectively (P < 0.05 for both comparisons). Subjects with preserved sympathetic innervation of the myocardium (H/M >/= 1.60) were at significantly lower risk of all-cause and cardiac death, arrhythmic events, sudden cardiac death, or potentially life-threatening arrhythmias. Within LVEF strata, a trend toward a higher mortality for subjects with H/M < 1.60 was observed reaching significance for LVEF 25 to /= 1.60 were at significantly lower risk of death and arrhythmic events independently of LVEF values.
ePub ahead of print