Warfarin for prevention of thromboembolism in atrial fibrillation: comparison of patient characteristics and outcomes of the "Real-World" Michigan Anticoagulation Quality Improvement Initiative (MAQI
Recommended Citation
Hughey AB, Gu X, Haymart B, Kline-Rogers E, Almany S, Kozlowski J, Besley D, Krol GD, Ahsan S, Kaatz S, Froehlich JB, Barnes GD. Warfarin for prevention of thromboembolism in atrial fibrillation: comparison of patient characteristics and outcomes of the "Real-World" Michigan Anticoagulation Quality Improvement Initiative (MAQI(2)) registry to the RE-LY, ROCKET-AF, and ARISTOTLE trials. J Thromb Thrombolysis.
Document Type
Article
Publication Date
10-1-2018
Publication Title
Journal of thrombosis and thrombolysis
Abstract
Randomized controlled trials (RCTs) examining warfarin use for stroke prevention in atrial fibrillation (AF) may not accurately reflect real-world populations. We aimed to determine the representativeness of the RCT populations to real-world patients and to describe differences in the characteristics of trial populations from trial eligible patients in a real-world setting. We hypothesized that a significant fraction of real-world patients would not qualify for the RE-LY, ROCKET-AF, and ARISTOTLE trials and that real-world patients qualifying for the studies may have more strokes and bleeding events. We compared the inclusion and exclusion criteria, patient characteristics, and clinical outcomes from RE-LY, ROCKET-AF, and ARISTOTLE against data from the Michigan Anticoagulation Quality Improvement Initiative (MAQI
Medical Subject Headings
Anticoagulants; Atrial Fibrillation; Female; Humans; Male; Michigan; Patient Selection; Quality Improvement; Randomized Controlled Trials as Topic; Registries; Thromboembolism; Treatment Outcome; Warfarin
PubMed ID
29948756
Volume
46
Issue
3
First Page
316
Last Page
324
