Authors

R. Thomas Lumbers
Sonia Shah
Honghuang Lin
Tomasz Czuba
Albert Henry
Daniel I. Swerdlow
Anders Mälarstig
Charlotte Andersson
Niek Verweij
Michael V. Holmes
Johan Ärnlöv
Per Svensson
Harry Hemingway
Neneh Sallah
Peter Almgren
Krishna G. Aragam
Geraldine Asselin
Joshua D. Backman
Mary L. Biggs
Heather L. Bloom
Eric Boersma
Jeffrey Brandimarto
Michael R. Brown
Hans-Peter Brunner-La Rocca
David J. Carey
Mark D. Chaffin
Daniel I. Chasman
Olympe Chazara
Xing Chen
Xu Chen
Jonathan H. Chung
William Chutkow
John G.F. Cleland
James P. Cook
Simon de Denus
Abbas Dehghan
Graciela E. Delgado
Spiros Denaxas
Alexander S. Doney
Marcus Dörr
Samuel C. Dudley
Gunnar Engström
Tõnu Esko
Ghazaleh Fatemifar
Stephan B. Felix
Chris Finan
Ian Ford
Francoise Fougerousse
René Fouodjio
Mohsen Ghanbari
Sahar Ghasemi
Vilmantas Giedraitis
Franco Giulianini
John S. Gottdiener
Stefan Gross
Daníel F. Guðbjartsson
Hongsheng Gui, Henry Ford Health SystemFollow
Rebecca Gutmann
Christopher M. Haggerty
Pim van der Harst
Åsa K. Hedman
Anna Helgadottir
Hans Hillege
Craig L. Hyde
Jaison Jacob
J. Wouter Jukema
Frederick Kamanu
Isabella Kardys
Maryam Kavousi
Kay-Tee Khaw
Marcus E. Kleber
Lars Køber
Andrea Koekemoer
Bill Kraus
Karoline Kuchenbaecker
Claudia Langenberg
Lars Lind
Cecilia M. Lindgren
Barry London
Luca A. Lotta
Ruth C. Lovering
Jian'an Luan
Patrik Magnusson
Anubha Mahajan
Douglas Mann
Kenneth B. Margulies
Nicholas A. Marston
Winfried März
John J.V. McMurray
Olle Melander
Giorgio Melloni
Ify R. Mordi
Michael P. Morley
Andrew D. Morris
Andrew P. Morris
Alanna C. Morrison
Michael W. Nagle
Christopher P. Nelson
Christopher Newton-Cheh
Alexander Niessner
Teemu Niiranen
Christoph Nowak
Michelle L. O'Donoghue
Anjali T. Owens
Colin N.A. Palmer
Guillaume Paré
Markus Perola
Louis-Philippe Lemieux Perreault
Eliana Portilla-Fernandez
Bruce M. Psaty
Kenneth M. Rice
Paul M. Ridker
Simon P.R. Romaine
Carolina Roselli
Jerome I. Rotter
Christian T. Ruff
Marc S. Sabatine
Perttu Salo
Veikko Salomaa
Jessica van Setten
Alaa A. Shalaby
Diane T. Smelser
Nicholas L. Smith
Kari Stefansson
Steen Stender
David J. Stott
Garðar Sveinbjörnsson
Mari-Liis Tammesoo
Jean-Claude Tardif
Kent D. Taylor
Maris Teder-Laving
Alexander Teumer
Guðmundur Thorgeirsson
Unnur Thorsteinsdottir
Christian Torp-Pedersen
Stella Trompet
Danny Tuckwell
Benoit Tyl
Andre G Uitterlinden
Felix Vaura
Abirami Veluchamy
Peter M. Visscher
Uwe Völker
Adriaan A. Voors
Xiaosong Wang
Nicholas J. Wareham
Peter E. Weeke
Raul Weiss
Harvey D. White
Kerri L. Wiggins
Heming Xing
Jian Yang
Yifan Yang
Laura M. Yerges-Armstrong
Bing Yu
Faiez Zannad
Faye Zhao
Jemma B. Wilk
Hilma Holm
Naveed Sattar
Steven A. Lubitz
David E. Lanfear, Henry Ford Health SystemFollow
Svati Shah
Michael E. Dunn
Quinn S. Wells
Folkert W. Asselbergs
Aroon D. Hingorani
Marie-Pierre Dubé
Nilesh J. Samani
Chim C. Lang
Thomas P. Cappola
Patrick T. Ellinor
Ramachandran S. Vasan
J. Gustav Smith

Document Type

Article

Publication Date

9-3-2021

Publication Title

ESC Heart Fail

Abstract

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.

METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10(-8) under an additive genetic model.

CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

PubMed ID

34480422

ePublication

ePub ahead of print

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