Cardiac Resynchronization Therapy and Clinical Outcomes in Continuous Flow Left Ventricular Assist Device Recipients

Authors

Rakesh Gopinathannair
Henri Roukoz
Adarsh Bhan
Ashwin Ravichandran
Mustafa M. Ahmed
Dmitry Familtsev
Geetha Bhat
Jennifer A. Cowger, Henry Ford HealthFollow
Munazzah Abdullah
Chirag Sandesara
Rahul Dhawan
Emma J. Birks
Jaimin R. Trivedi
Mark S. Slaughter

Recommended Citation

Gopinathannair R, Roukoz H, Bhan A, Ravichandran A, Ahmed MM, Familtsev D, Bhat G, Cowger J, Abdullah M, Sandesara C, Dhawan R, Birks EJ, Trivedi JR, Slaughter MS. Cardiac resynchronization therapy and clinical outcomes in continuous flow left ventricular assist device recipients. J Am Heart Assoc.

Document Type

Article

Publication Date

6-15-2018

Publication Title

J Am Heart Assoc

Abstract

BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients.

METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015. Effects of CRT on mortality, hospitalizations, and ventricular arrhythmia incidence were compared against CF-LVAD patients with an ICD alone. Baseline differences were noted between the 2 groups in age (60±12 versus 55±14,

CONCLUSIONS: In this large, multicenter CF-LVAD cohort, continued CRT was not associated with improved survival, hospitalizations, incidence of ventricular arrhythmia and ICD therapies, and was related to a significantly higher number of pulse generator changes.

Comments

© authors, original version available at 10.1161/JAHA.118.009091

Creative Commons Attribution Non-Commercial License

PubMed ID

29907652

Volume

7

Issue

12