Trends and Outcomes of Left Ventricular Assist Device Therapy: JACC Focus Seminar

Document Type

Article

Publication Date

3-22-2022

Publication Title

Journal of the American College of Cardiology

Abstract

As the prevalence of advanced heart failure continues to rise, treatment strategies for select patients include heart transplantation or durable left ventricular assist device (LVAD) support, both of which improve quality of life and extend survival. Recently, the HeartMate 3 has been incorporated into clinical practice, the United Network for Organ Sharing donor heart allocation system was revised, and the management of LVAD-related complications has evolved. Contemporary LVAD recipients have greater preoperative illness severity, but survival is higher and adverse event rates are lower compared with prior eras. This is driven by advances in device design, patient selection, surgical techniques, and long-term management. However, bleeding, infection, neurologic events, and right ventricular failure continue to limit broader implementation of LVAD support. Ongoing efforts to optimize management of patients implanted with current devices and parallel development of next-generation devices are likely to further improve outcomes for patients with advanced heart failure.

Medical Subject Headings

Heart Failure; Heart Transplantation; Heart-Assist Devices; Humans; Quality of Life; Tissue Donors; Treatment Outcome

PubMed ID

35300822

Volume

79

Issue

11

First Page

1092

Last Page

1107

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