Cardiopulmonary Exercise Measures of Men and Women with HFrEF Differ in Their Relationship to Prognosis: The Henry Ford Hospital Cardiopulmonary Exercise Testing (FIT-CPX) Project.
Ehrman JK, Brawner CA, Shafiq A, Lanfear DE, Saval M, Keteyian SJ. Cardiopulmonary exercise measures of men and women with hfref differ in their relationship to prognosis: The henry ford hospital cardiopulmonary exercise testing (fit-cpx) project. J Card Fail.
Journal of cardiac failure
BACKGROUND: This study evaluated if different prognostic characteristics exist for peak oxygen consumption (VO
METHODS: Analysis of the Henry Ford Hospital Cardiopulmonary Exercise Testing database (n = 1085; 33% women, 55% black) of individuals with HFrEF who completed a physician-referred cardiopulmonary exercise testing (CPX) between 1997 and 2010. Primary outcome was a composite of all-cause death, left ventricular assist device placement, and orthotopic heart transplant . Logistic and Cox regressions were performed and Kaplan-Meier survival curves were developed to describe relationships of the CPX variables and the composite outcome within and between men and women.
RESULTS: All patients were followed-up for a minimum of 5 years, during which there were 643 combined events (62%; 499 deaths, 64 left ventricular assist device implants, 80 orthotopic heart transplant). Each CPX variable was significantly related to event-free survival among both men and women. Log-rank assessment of Kaplan-Meier curves noted survival differences for peak VO
CONCLUSIONS: Prognostic values for peak VO
Medical Subject Headings
Cause of Death; Disease Progression; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Heart Failure; Humans; Male; Michigan; Middle Aged; Oxygen Consumption; Prognosis; Retrospective Studies; Sex Factors; Stroke Volume; Survival Rate