Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia
Mawri S, Gildeh E, Joseph N, Rabbani B, Zweig B. Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia. Case Rep Cardiol. 2017.
Case Rep Cardiol
Magnesium is the second most common intracellular cation and serves as an important metabolic cofactor to over 300 enzymatic reactions throughout the human body. Among its various roles, magnesium modulates calcium entry and release from sarcoplasmic reticulum and regulates ATP pumps in myocytes and neurons, thereby regulating cardiacand neuronal excitability. Therefore, deficiency ofthis essential mineral may result in serious cardiovascular and neurologic derangements. In this case, we present the clinical course of a 76-year-old woman who presented with marked cardiac and neurological signs and symptoms which developed as a result of severe hypomagnesemia. The patient promptly responded to magnesium replacement once the diagnosis was established. We herein discuss the clinical presentation, pathophysiology, diagnosis, and management of severe hypomagnesemia and emphasize the implications ofmagnesium deficiency in the cardiovascular and central nervous systems. Furthermore, this case highlights the importance of having high vigilance for hypomagnesemia in the appropriate clinical setting.