LONG TERM OUTCOMES OF TAKOTSUBO CARDIOMYOPATHY IN MEN COMPARED TO WOMEN IN THE US VETERAN AFFAIRS HEALTHCARE SYSTEM
Alqam B, Habash F, Gheith Z, Vallurupalli S, and Maskoun W. LONG TERM OUTCOMES OF TAKOTSUBO CARDIOMYOPATHY IN MEN COMPARED TO WOMEN IN THE US VETERAN AFFAIRS HEALTHCARE SYSTEM. Journal of the American College of Cardiology 2021; 77(18):867.
Journal of the American College of Cardiology
Background: Takotsubo cardiomyopathy is characterized by significant transient left ventricular dysfunction. Differences in long term outcome in men compared to women is not well described in the literature.
Methods: We performed a retrospective study using chart review for patients diagnosed with Takotsubo Cardiomyopathy between 2005 and 2018 in the Veteran Affairs (VA) national database. We included patients who met the Mayo Clinic diagnostic criteria for Takotsubo Cardiomyopathy. We compared the long term outcomes in men vs women patients.
Results: 641 patients were included, of those 69.3% were males, median age was 64 years, median ejection fraction at the time of diagnosis was 35. On Kaplan-Meier analysis there was no significant difference between men and women in the rates of recurrence of Takotsubo at median follow up of 4 years, or arrhythmia at 1 year (Figure-1 A and B respectively). However, men had higher mortality rate over 10 year follow up period (Figure-1 C).
Conclusion: In patients with Takotsubo cardiomyopathy at the VA system, men had higher mortality rates but there was not significant difference in rates of recurrence or arrhythmias when compared to women.