TCT-71 Characteristics and Outcomes of Men and Women Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention: Individual Patient Data Pooled Analysis of 4 Multicenter Registries
Nikolakopoulos I, Quadros A, Dens J, Rafeh NA, Agostoni P, Alaswad K, Avran A, Belli K, Campos C, Carlino M, Choi J, De Los Santos FD, ElGuindy A, Jaffer FA, Karmpaliotis D, Khatri J, Khelimskii D, Knaapen P, Krestyaninov O, La Manna A, Lamelas P, Ojeda S, Padilla L, Piccaro de Oliveira P, Rinfret S, Santiago R, Spratt J, Walsh S, Kostantinis S, Simsek B, Karacsonyi J, Rangan B, Vemmou E, Brilakis E, and Azzalini L. TCT-71 Characteristics and Outcomes of Men and Women Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention: Individual Patient Data Pooled Analysis of 4 Multicenter Registries. J Am Coll Cardiol 2021; 78(19):B29-B30.
J Am Coll Cardiol
Background: Sex-specific outcomes of chronic total occlusion percutaneous coronary intervention (CTO PCI) have received limited study.
Methods: We examined the clinical and angiographic characteristics and procedural outcomes of 11,525 CTO PCIs performed on 11,421 patients (1,901 women and 9,520 men) at 107 centers in Europe, North America, Latin America, and Asia between 2012 and 2020, pooling patient-level data from 4 multicenter registries.
Results: Women comprise 20% of CTO PCI patients, and their share among all CTO PCI patients has increased over time (Figure 1). Women are older, more likely to have diabetes, and to present with lower angiographic complexity scores (Table 1). Women have higher technical (88% vs 85%, P < 0.001) and procedural success (86% vs 84%, P = 0.03) and higher rates of tamponade (1.1% vs 0.7%, P = 0.04). Procedural success in women was more frequently achieved by antegrade wiring.
Conclusion: Women who undergo CTO PCI have less complex lesions than men. CTO PCI in women is associated with higher success rates but also higher rates of tamponade.