Title

Alcohol use disorder among chronic hepatitis C patients: prevalence and treatment outcomes, CHeCS, 2006-2013

Document Type

Conference Proceeding

Publication Date

2016

Publication Title

Hepatology

Abstract

Background: Alcohol use in patients with chronic hepatitis C (CHC) results in progression of liver disease and represents a barrier to antiviral therapy. We sought to determine the prevalence of alcohol abuse and alcohol-related liver disease among CHC patients to assess their access to HCV treatment. Methods: We used CHeCS data collected from CHC patients seen in four large U.S. healthcare systems from 2006-2013. Among patients with documented ICD 9 codes indicative of any alcohol use disorder defined as alcohol abuse/dependence and alcohol-related liver disease, we determined the percentage of patients with any alcohol disorder, with alcohol abuse/dependence, and with alcohol-related liver disease who received HCV treatment. We used multivariable analysis to identify factors associated with HCV treatment by alcohol status. Results: Of the 11,636 CHC patients, 3,553 (30.5%) had at least one documented ICD-9 code indicative of any alcohol use disorder. Among those with any alcohol use disorder, 70.4% were male, 92.5% were aged >44 years, 58.7% were white, and 19.9% had alcohol-related liver disease. Overall, 40.3% of CHC patients received HCV treatment. Only 30.4% of those with alcohol abuse and 50.4% of those with alcohol-related liver disease received treatment. Sustained virologic response rates were 41.6% overall, 44.7% for those with alcohol abuse, and 28.4% for those with alcohol-related liver disease. In univariate analysis HCV treatment was associated with age, race, household income, ever having biopsy and biopsy stage (p

Volume

64

Issue

S1

First Page

873A

Last Page

874A

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