Title

TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.

Document Type

Article

Publication Date

6-1-2016

Publication Title

Allergy

Abstract

Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor-β1 (TGF-β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.

Medical Subject Headings

Animals; Cell Differentiation; Gene Expression Regulation; Humans; Langerhans Cells; Protein Binding; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta1

PubMed ID

26948524

Volume

71

Issue

6

First Page

758

Last Page

764

Share

COinS