TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.
Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor-β1 (TGF-β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.
Medical Subject Headings
Animals; Cell Differentiation; Gene Expression Regulation; Humans; Langerhans Cells; Protein Binding; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta1