Title

Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies.

Document Type

Article

Publication Date

7-1-2016

Publication Title

Immunotherapy

Abstract

Atopic dermatitis (AD), a chronic, relapsing, inflammatory skin disease that is characterized by intense pruritus and eczematous lesions with up to 90% of patients presenting with mild to moderate disease. Current topical treatments for AD have not changed in over 15 years and are associated with safety concerns. In AD, overactivity of phosphodiesterase 4 (PDE4), leads to inflammation and disease exacerbation. Crisaborole Topical Ointment, 2%, is a novel, nonsteroidal, topical anti-inflammatory PDE4 inhibitor currently being investigated for the treatment of mild to moderate AD. Preliminary studies in children and adults demonstrated favorable efficacy and safety profiles. Crisaborole may represent an anti-inflammatory option that safely minimizes the symptoms and severity of AD and that can be used for both acute and long-term management.

Medical Subject Headings

Administration, Topical; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Child; Clinical Trials as Topic; Dermatitis, Atopic; Humans; Ointments; Phosphodiesterase 4 Inhibitors

PubMed ID

27283509

Volume

8

Issue

8

First Page

853

Last Page

866

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