Title

Itch relief in patients with psoriasis: effectiveness of calcipotriol plus betamethasone dipropionate foam.

Document Type

Article

Publication Date

12-6-2018

Publication Title

Journal of the European Academy of Dermatology and Venereology : JEADV

Abstract

BACKGROUND: Itch is common in psoriasis, adversely affecting health-related quality of life (HRQoL) and sleep.

OBJECTIVE: We evaluated the efficacy of topical fixed-dose combination calcipotriol 50 μg/g plus betamethasone dipropionate 0.5 mg/g cutaneous foam (Cal/BD foam) on itch, itch-related sleep loss and HRQoL versus foam vehicle.

METHODS: We pooled data from three Phase II/III trials (NCT01536886/NCT01866163/NCT02132936) of Cal/BD foam versus foam vehicle in adults with mild-severe psoriasis. For itch-related analyses, patients with baseline itch VAS >40 (range 1-100) were analysed. Outcomes included: itch VAS reduction >40, ≥70% improvement in itch (Itch70) or itch-related sleep loss, 75% improvement in modified PASI (excluding head) (mPASI75), and Dermatology Life Quality Index (DLQI) scores 0/1 through 4 weeks.

RESULTS: Of 837 patients, 800 had baseline itch VAS >0 (Cal/BD foam, n=610; foam vehicle, n=190); 484 had baseline itch VAS >40. There was no correlation between itch VAS score and mPASI at baseline (R

CONCLUSION: Compared with foam vehicle, Cal/BD foam offers more rapid and effective itch relief, with associated significant improvements in sleep and DLQI. This article is protected by copyright. All rights reserved.

PubMed ID

30520168

ePublication

ePub ahead of print

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