Ivermectin 1% cream for rosacea.
Skin therapy letter
The etiology of papulopustular rosacea (PPR) is not well understood yet appears to involve both the innate and adaptive immune response in addition to possible infestation with Demodex mites. Current treatments for PPR consist mainly of antibiotics. Ivermectin cream 1%, a new topical treatment for PPR, possesses both anti-inflammatory and anti-parasitic properties. After 12 weeks of treatment, subjects treated with ivermectin cream 1% had significantly greater reductions in PPR symptoms and enhanced diseaserelated quality of life improvements compared to subjects who received vehicle. Furthermore, PPR symptoms continued to improve with prolonged treatment (40 weeks). Ivermectin cream 1% offers a multi-pronged approach to combat the complex pathophysiology of rosacea.
Medical Subject Headings
Administration, Topical; Anti-Infective Agents; Antiparasitic Agents; Clinical Trials, Phase III as Topic; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; Ivermectin; Male; Metronidazole; Middle Aged; Rosacea; Skin Cream