HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.
Liu Q, Zhang X, Yin C, Chen X, Gang Zhang Z, Brown S, Xie H, Zhou L, Mi Q. HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.. Oncotarget 2017; 8(11):17562-17572.
Histone deacetylation, reciprocally mediated by histone deacetylases (HDAC) and acetyltransferases, represents one major form of post-translational modification. Previous research indicates that HDACs play an essential regulatory role in the development of various immune cells. However, the specific function of individual HDACs remains largely unexplored. HDAC4, a member of class II HDACs, profoundly investigated in the nervous system, while the expression profile and function of HDAC4 in T cells are barely known. For the first time, we report here that HDAC4 is expressed in the multiple T cell lineages. Using T-cell-specific HDAC4-deficient mice, we discovered that lack of HDAC4 did not alter the frequencies of conventional T cells, invariant NKT (iNKT) cells or regulatory T cells within both the thymus and secondary lymphoid organs. Moreover, conventional T cells and iNKT cells from wild-type and HDAC4-deficient mice displayed no significant difference in cytokine production. In conclusion, our results imply that under steady stage, HDAC4 is not required for the development and function of multiple T cell lineages, including conventional T cells and iNKT cells.
Medical Subject Headings
Animals; Cell Differentiation; Cell Lineage; Cell Separation; Female; Flow Cytometry; Histone Deacetylases; Lymphopoiesis; Male; Mice; Mice, Knockout; Models, Animal; Polymerase Chain Reaction; T-Lymphocytes