Title

Addressing the immunopathogenesis of atopic dermatitis: advances in topical and systemic treatment.

Document Type

Article

Publication Date

3-1-2017

Publication Title

Seminars in cutaneous medicine and surgery

Abstract

Several immunologic mediators-phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase-have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process. Several new topical medications have been developed that target the enzyme PDE; crisaborole was recently approved by the US Food and Drug Administration (FDA) for the treatment of atopic dermatitis, and phase II studies have been completed on OPA-15406. The phase III clinical trial results of the systemic medication dupilumab, an inhibitor of the IL-4 receptor α subunit (which inhibits both IL-4 and IL-13 signaling), are currently being reviewed by the FDA.

Medical Subject Headings

Antibodies, Monoclonal; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Dermatologic Agents; Humans; Interleukin-4 Receptor alpha Subunit; Phosphodiesterase 4 Inhibitors

PubMed ID

28654711

Volume

36

Issue

2 Suppl 2

First Page

S45

Last Page

S48

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