A case of salivary gland hyalinizing clear cell carcinoma (HCCC) with cutaneous metastasis
Shaar RA, Zia S, Alhamar M, and Friedman BJ. A case of salivary gland hyalinizing clear cell carcinoma (HCCC) with cutaneous metastasis. American Journal of Dermatopathology 2021; 43(SUPPL 8):S1.
American Journal of Dermatopathology
Hyalinizing clear cell carcinoma (HCCC) is a rare malignant tumor of the minor salivary glands with low-grade morphology and generally favorable outcome. In up to 16.4% of cases, aggressive disease and metastasis has been reported. We report the case of a 44 year-old female with history of HCCC arising at the base of her tongue which had the typical EWSR1-ATF1 fusion. She received wide local excision followed by adjuvant radiation, chemotherapy and immunotherapy. However, over the following few years, the tumor metastasized to multiple visceral sites. Interestingly, she also developed two closely adjacent nodules on her scalp which demonstrated variably sized aggregations of atypical pale-cuboidal cells with surrounding sclerosis filling the dermis and abutting the epidermis, morphologically resembling her previously known HCCC. To our knowledge, this is the first reported case HCCC with cutaneous metastasis, which is noteworthy because it can cause diagnostic confusion given the morphologic and immunophenotypic similarity to other primary skin adnexal tumors.