26905 The effect of Polypodium leucotomos extract (Fernblock) on visible light and UV-induced photoaging

Document Type

Conference Proceeding

Publication Date


Publication Title

J Am Acad Dermatol


Traditional sunscreens containing organic ultraviolet (UV) filters have increasingly been scrutinized for their effects on the environment. As a result there has been an interest in environmentally safe polyphenol compounds as adjuvants which also provide systemic protection against different wavelengths of solar radiation. Fernblock the patented, standardized extract of Polypodium leucotomos, herein referred to as PLE, is an antioxidant widely available as oral supplement for photoprotection. We performed a comprehensive review of the available literature on the effect of PLE on UV and visible light (VL) induced photoaging. PLE increases TGF-β, type I and V collagen and elastin in UV-irradiated fibroblasts, as well as increased elastin and fibrillin 1 expression and decreased MMP-1 expression in VL-irradiated fibroblasts. PLE also decreases UVR-induced TNF-α, NO, iNOS, NF-kB and AP1 in keratinocytes. In murine models PLE increases catalase and glutathione peroxidase activity in the epidermis, inhibits dermal elastosis, decreases skin inflammatory cells and COX-2 levels, and reinforces dermal elastic fibers. In human skin, PLE prevents both VL and UV-induced COX-2 expression and VL-induced MMP-1 expression. Enhanced antioxidative protection of the skin was noted in human skin in vivo after consumption of an antioxidant supplement containing non-Fernblock extract of P leucotomos. PLE may protect against UV- and VL-induced photoaging through regulation of extracellular matrix (ECM) modeling, specifically via TGF-β signaling and MMP transcription factors, and downregulation of inflammation due to its anti-inflammatory and antioxidant properties. Future large-scale studies assessing the photoprotective effects of PLE in humans are warranted.







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