25602 Improvements and response achievement in PASI subscale domains for head scaling and erythema in apremilast-treated patients with moderate to severe plaque psoriasis of the scalp: Results from the STYLE study

Document Type

Conference Proceeding

Publication Date

9-1-2021

Publication Title

J Am Acad Dermatol

Abstract

Background: Up to 80% of patients with psoriasis have scalp involvement. Apremilast 30 mg BID (APR) demonstrated efficacy in the phase 3 STYLE study of moderate-to-severe scalp psoriasis. We report a post hoc analysis of the head scaling and head erythema PASI subscale domains.

Methods: Patients with moderate-to-severe plaque psoriasis (PASI ≥12, BSA ≥10%, sPGA ≥3) and moderate-to-severe scalp psoriasis (baseline Scalp PGA score ≥3, psoriasis-involved scalp surface area ≥20%) with inadequate response/intolerance to ≥1 topical therapy were randomized to double-blind treatment with APR or placebo (PBO) for 16 weeks.

Results: Baseline mean (SD) PASI head scaling scores were 2.8 (0.7) for APR (n = 201) and PBO (n = 102); head erythema scores were 2.9 (0.6) and 2.8 (0.6). Significantly greater mean percentage changes from baseline were observed at Week 16 with APR vs PBO in head scaling (APR: −52.2 [95% CI: −57.9, −46.4] vs PBO: −26.9 [95% CI: −34.4, −19.4]) and head erythema scores (APR: −53.1 [95% CI: −59.1, −47.2] vs PBO: −25.0 [95% CI: −32.0, −17.9]). Improvements were observed as early as Week 2. Significantly more APR vs PBO patients achieved Week 16 responses (score of 0 [none] or 1 [slight]) on head scaling (55.4% [95% CI: 47.5, 63.0] vs 31.0% [95% CI: 21.3, 42.0]; P =.0002) and erythema (55.4% [95% CI: 47.5, 63.0] vs 23.8% [95% CI: 15.2, 34.3]; P ˂.0001).

Conclusions: Patients with moderate-to-severe scalp psoriasis had greater improvements in PASI subscale scores (head scaling, head erythema); greater proportions of patients achieved head scaling and erythema responses with APR vs PBO.

Comments

https://doi.org/10.1016/j.jaad.2021.06.276

Volume

85

Issue

3

First Page

AB63

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