Systemic therapy of atopic dermatitis: Welcome to the revolution
Eichenfield LF, Stein Gold LF. Systemic therapy of atopic dermatitis: Welcome to the revolution. Semin Cutan Med Surg 2017; 36(Suppl 4):S103-S105.
Semin Cutan Med Surg
Until recently, systemic therapy of atopic dermatitis was limited to off-label use of immunomodulators, which can pose significant safety concerns, and treatment with systemic corticosteroids, not recommended in the most recent guidelines. The introduction of dupilumab in 2017 marked a major advance in systemic therapy for atopic dermatitis. It has demonstrated long-term efficacy in adults with moderate to severe disease, and is being studied in children. Several other biologic agents and "small molecules" with varying mechanisms of action are in phase 2 or 3 development. (C) 2017 published by Frontline Medical Communications