Continuous Glucose Monitoring Profiles in Healthy Non-Diabetic Participants: A Multicenter Prospective Study.
Shah VN, DuBose SN, Li Z, Beck RW, Petesrs AL, Weinstock RS, Kruger D, Tansey M, Sparling D, Woerner S, Vendrame F, Bergenstal R, Tamborlane WV, Watson SE, and Sherr J. Continuous Glucose Monitoring Profiles in Healthy Non-Diabetic Participants: A Multicenter Prospective Study. J Clin Endocrinol Metab 2019; Epub ahead of print.
The Journal of clinical endocrinology and metabolism
CONTEXT: Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. While data on glycemic profiles of healthy, non-diabetic individuals exists for older sensors, assessment of glycemic metrics with new generation CGM devices is lacking.
OBJECTIVE: To establish reference sensor glucose ranges in healthy, non-diabetic individuals across different age groups, using a current generation CGM sensor.
DESIGN: Multicenter, prospective study.
SETTING: 12 centers within the T1D Exchange Clinic Network.
PATIENTS OR PARTICIPANTS: Non-pregnant, healthy, non-diabetic children and adults (age ≥6 years); with non-obese body mass index.
INTERVENTION: A blinded Dexcom G6 CGM, with once daily calibration, was worn for up to 10 days in each participant.
MAIN OUTCOME MEASURE: CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability.
RESULTS: 153 participants (age 7-80 years) were included in the analyses. Mean average glucose was 98-99 mg/dL (5.4-5.5 mmol/L) for all age groups except those over 60 years in whom mean average glucose was 104 mg/dL (5.8 mmol/L). The median % time between 70-140 mg/dL (3.9-7.8 mmol/L) was 96% (IQR 93%-98%). Mean within-individual coefficient of variation (CV) was 17±3%. Median time spent with glucose levels >140mg/dL was 2.1% (30 min/day) and/dL (3.9 mmol/L) was 1.1% (15 min/day).
CONCLUSION: By assessing across age groups in a healthy, non-diabetic population, normative sensor glucose data have been derived, and will be useful as a benchmark for future research studies.
ePub ahead of print