Continuous Glucose Monitoring Profiles in Healthy Non-Diabetic Participants: A Multicenter Prospective Study

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The Journal of clinical endocrinology and metabolism


CONTEXT: Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. While data on glycemic profiles of healthy, non-diabetic individuals exists for older sensors, assessment of glycemic metrics with new generation CGM devices is lacking.

OBJECTIVE: To establish reference sensor glucose ranges in healthy, non-diabetic individuals across different age groups, using a current generation CGM sensor.

DESIGN: Multicenter, prospective study.

SETTING: 12 centers within the T1D Exchange Clinic Network.

PATIENTS OR PARTICIPANTS: Non-pregnant, healthy, non-diabetic children and adults (age ≥6 years); with non-obese body mass index.

INTERVENTION: A blinded Dexcom G6 CGM, with once daily calibration, was worn for up to 10 days in each participant.

MAIN OUTCOME MEASURE: CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability.

RESULTS: 153 participants (age 7-80 years) were included in the analyses. Mean average glucose was 98-99 mg/dL (5.4-5.5 mmol/L) for all age groups except those over 60 years in whom mean average glucose was 104 mg/dL (5.8 mmol/L). The median % time between 70-140 mg/dL (3.9-7.8 mmol/L) was 96% (IQR 93%-98%). Mean within-individual coefficient of variation (CV) was 17±3%. Median time spent with glucose levels >140mg/dL was 2.1% (30 min/day) and/dL (3.9 mmol/L) was 1.1% (15 min/day).

CONCLUSION: By assessing across age groups in a healthy, non-diabetic population, normative sensor glucose data have been derived, and will be useful as a benchmark for future research studies.

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ePub ahead of print