Zohra Chaudhry Amit Vahia Sally Askar Noman Hussain Mujtaba Hameed George J. Alangaden
Henry Ford Health System
05-01-2019
Background: Candidemia is associated with a 30-day mortality of 20-40%, with likelihood of death increasing by 50% for each day therapy is delayed. T2 Candida is approved by the FDA for the diagnosis ..
Background: Candidemia is associated with a 30-day mortality of 20-40%, with likelihood of death increasing by 50% for each day therapy is delayed. T2 Candida is approved by the FDA for the diagnosis of candidemia with a sensitivity of 90% and specificity of 98%. The mean time to Candida detection is estimated to be 4.4 hours. Standard blood culture turnaround time is 3 days. Prompt diagnosis is essential to effectively treat candida infection. Methods: Retrospective analyses were conducted on 70 T2MR positive patients. The primary endpoint is time to de-escalation fromechinocandin to fluconazole based on T2 species identified. Secondary endpoints are time to T2 positivity and identification of risk factors for mortality and clinical outcomes of invasive candidiasis (IC).Univariate logistic regression was used to determine association between individual risk factors and primary outcomes. Multivariate Logistic regression models were created using forward selection to model the odds of IC and mortality. Time to de-escalation of echinocandins were modeled using Kaplan-Meier estimators. Results: Univariate analysis showed statistically significant associations between mortality and sepsis diagnosis, hypotension, abnormal WBC count, and tachycardia (P
