Vitamin d and autoimmune hepatitis: Systemic review and meta-analysis

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Conference Proceeding

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Background: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that, if left untreated, can lead to liver failure and/or cirrhosis. AIH affects children and adults of all ages. It has a variable course, with periods of increased or decreased activity. A low Vitamin D level has been associated with autoimmune illnesses such as primary sclerosis cholangitis and primary biliary cirrhosis in several studies. Even though vitamin D has been demonstrated to have various immunomodulatory effects, little is known regarding its impact on the severity of autoimmune hepatitis. To determine the effects of low vitamin D levels on the severity of autoimmune hepatitis, including progression of advanced fibrosis, we conducted a systematic review and meta-analysis of the available studies. Methods: We systematically searched the following databases: PubMed/Medline, Embase, Cochrane Register of Controlled Trials, and Web of Science through April 2021 to include all the crosssectional studies. The individuals' characteristics, as well as outcome measurements such as advanced liver fibrosis, were analyzed. Random effects model using the DerSimonian-Laird approach was employed, and odds ratios (OR) with 95% confidence interval (CI) were calculated. Results: 4 Studies (3 Cohort studies and 1 Abstract) with a total of 406 patients were included. The patients were 43 years old on average when they were diagnosed with AIH, and 79 percent of them were female. Each study used a different cut-off value for vitamin D. Patients with comparatively low vitamin D levels had a lower risk of advanced fibrosis (pooled OR 0.47 95% CI 0.26-0.87, P-value 0.02). Heterogeneity among studies was low as seen by the I2 of 23% for Hepatic Fibrosis. Conclusion: Vitamin D has been demonstrated to have several immunomodulatory effects and lower vitamin D levels have been linked to a lower risk of advanced fibrosis in this meta-analysis and systemic review. However, further studies, including randomized controlled trials, are warranted to further establish this association.

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Not assigned.





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