The impact of spontaneous bacterial peritonitis on patient outcomes after liver transplantation using the scientific registry of transplant recipient (SRTR) database
Moonka D, Divine G, and Nagai S. The impact of spontaneous bacterial peritonitis on patient outcomes after liver transplantation using the scientific registry of transplant recipient (SRTR) database. Am J Transplant 2018; 18:843.
Am J Transplant
Spontaneous bacterial peritonitis (SBP) is associated with abdominal inflammation and increased morbidity in patients with end-stage liver disease. However, SBP has generally not been associated with worse outcomes after liver transplantation (LT) in single center studies. In this analysis, we analyze the impact of a history of SBP on LT outcomes using the SRTR database. METHODS: All patients, 18 years or older, who received an initial LT alone between March 2002 and December 2016 were included leaving 75,576 patients. 2262 were missing SBP data leaving 73,314. Of these 4665 had SBP and 68,649 did not. The two groups were compared for patient and donor characteristics. Groups were compared for length of stay (LOS) and survival using Kaplan-Meier analyses with log rank test. Multivariate analysis was done using Cox regression analysis. RESULTS: Patients with a history of SBP were more ill than those without. They had a higher MELD at LT (26.1 + 10.0 vs 20.7 + 10.3: P