p16 positive oropharyngeal small cell cancer: A case report
Recommended Citation
Al Masalmeh N, Kukreja G, Zaiem F, Raza SN, Kim H, Nagasaka M, and Sukari A. p16 positive oropharyngeal small cell cancer: A case report. Oral Oncol 2021; 121:105391.
Document Type
Article
Publication Date
10-1-2021
Publication Title
Oral oncology
Abstract
Extra-pulmonary small cell carcinomas (EPSCC) are rare malignancies. Like small cell lung cancer (SCLC), they are aggressive malignancies with dismal prognosis. We here report a case of a middle-aged man who presented with odynophagia and cervical lymphadenopathy. Diagnostic workup confirmed the diagnosis of locally-advanced p16-positive oropharyngeal cancer (OPC) with a surprising histology of small cell cancer, suggesting a human papilloma virus (HPV)-related oropharyngeal cancer with small cell differentiation. HPV oropharynx infection is a well-known risk factor for squamous cell carcinoma of the oropharynx, but it is unknown if it may increase the risk of other OPC histology.
PubMed ID
34187735
Volume
121
First Page
105391
Last Page
105391
