A Retrospective Study Analyzing the Appropriateness of Initial Treatment of
Fisher A, Khanal P, Gniado E, Khaddour L, Orosey M, Hader I, Yadav S, and Halalau A. A retrospective study analyzing the appropriateness of initial treatment of clostridium difficile in patients with active malignancy. Gastroenterol Res Pract 2018; 2018:7192728.
Gastroenterol Res Pract
Methods: This is a retrospective study of adult patients admitted with CDI and any underlying active malignancy at Beaumont Hospital, Royal Oak, Michigan, from January 2008 to December 2014. Inclusion criteria included age > 18 years old, polymerase chain reaction- (PCR-) proven CDI, and active malignancy.
Results: 197 patients were included in the final analysis. 44.8% of the metronidazole group required escalation of therapy compared to 15.2% in the vancomycin group (
Discussion: Our results support the initial use of vancomycin or a combination (metronidazole and vancomycin) versus metronidazole in patients with CDI and active malignancy.