Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia
Emole J, Lawal O, Lupak O, Rangarajan H, and Udo I. Neuropsychiatric disorders in adults undergoing chimeric antigen receptor T cells therapy for aggressive lymphomas and acute lymphoblastic leukemia. Leuk Res Rep 2023; 19:100364.
Leuk Res Rep
OBJECTIVE: To evaluate risk factors for neuropsychiatric disorders (NPD) in recipients of CART therapy.
METHODS: Patients ≥ 18 years with acute lymphoblastic leukemia (ALL), and aggressive B-cell lymphomas who received CART in 2018 were evaluated. Patients with and without NPD were compared.
RESULTS: NPD was diagnosed in 31.2% of patients. Compared to patients without NPD, patients with NPD were likely to be females (P = 0.035) and have ALL (P = 0.039). NPD was significantly associated with female gender (OR = 2.03) and diagnosis of ALL (OR = 2.76). No association between NPD and outcomes.
CONCLUSIONS: Female gender and ALL were risk factors for NPD.