Approach to the Older Patient with Acute Myeloid Leukemia
Recommended Citation
Zimmer M, and Kadia T. Approach to the Older Patient with Acute Myeloid Leukemia. Curr Oncol Rep 2023.
Document Type
Article
Publication Date
11-1-2023
Publication Title
Current oncology reports
Abstract
PURPOSE OF REVIEW: This study aims to review the challenges of treating AML in older patients, the spectrum of genomic aberrancies in this cohort, and discuss treatment options for newly diagnosed AML in this patient population.
RECENT FINDINGS: Greater understanding of biological underpinnings of AML and availability of newer, effective, targeted therapies have allowed us to move away from intensification of chemotherapy, to prioritize better tolerability while still maintaining efficacy. Increasing knowledge of the genomic complexity and adverse karyotypes in older AML patients drives the need for ongoing investigations of targeted and lower-intensity therapies in the frontline, relapsed/refractory setting, and post-remission.
Medical Subject Headings
Humans; Aged; Leukemia, Myeloid, Acute; Antineoplastic Combined Chemotherapy Protocols
PubMed ID
37688738
ePublication
ePub ahead of print
Volume
25
Issue
11
First Page
1203
Last Page
1211
