Thilagar B, Beidoun M, Rhoades R, and Kaatz S. COVID-19 and thrombosis: searching for evidence. Hematology Am Soc Hematol Educ Program 2021; 2021(1):621-627.
Hematology Am Soc Hematol Educ Program
Early in the pandemic, COVID-19-related increases in rates of venous and arterial thromboembolism were seen. Many observational studies suggested a benefit of prophylactic anticoagulation for hospitalized patients using various dosing strategies. Randomized trials were initiated to compare the efficacy of these different options in acutely ill and critically ill inpatients as the concept of immune-mediated inflammatory microthrombosis emerged. We present a case-based review of how we approach thromboembolic prophylaxis in COVID-19 and briefly discuss the epidemiology, the pathophysiology, and the rare occurrence of vaccine-induced thrombotic thrombocytopenia.
Medical Subject Headings
Anticoagulants; Blood Coagulation; COVID-19; COVID-19 Vaccines; Critical Illness; Humans; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopathic; Risk Factors; Thrombosis