Diagnostic accuracy of elastography in patients with liver cirrhosis

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Conference Proceeding

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Background: Liver cirrhosis is one of the most common causes of death worldwide. Recently trending transient elastography is gaining importance as a non-invasive procedure in staging liver fibrosis. However, not much is known about its diagnostic accuracy. Hence, we aim to conduct meta-meta-analysis to assess the diagnostic accuracy of transient elastography in diagnosing stage 4 fibrosis/liver cirrhosis in patients with chronic liver disease (CLD) compared to gold standard liver biopsy. Methods: A systematic search was performed following PRISMA guidelines of meta-analysis studies that evaluated the diagnostic accuracy of transient elastography in detecting liver cirrhosis (F4) according to Metavir scoring system compared with liver biopsy using PubMed database from inception to May 2021. We performed a random-effects model irrespective of heterogeneity to estimate sensitivity, specificity, and diagnostic odds ratio (OR) and their 95% Confidence interval (CI). Results: Five meta-analysis studies were included with a total of 124 studies included in these meta-analysis. We found 84.8 % pooled sensitivity (95%CI: 81.4%-87.7%) (I2= 86.4%;p<0.001), 87.5% pooled specificity (95%CI: 85.4%-89.3%) (I2= 90%;p<0.001) of transient elastography in diagnosing liver cirrhosis compared to liver biopsy. We found that transient elastography had higher odds of diagnosing liver cirrhosis in chronic liver disease patients (diagnostic OR:41.8; 95% CI: 3.9-56.5) (I2= 87%; p<0.001). [Figure 1] Conclusion: Our meta-meta-analysis suggests that non-invasive transient elastography had higher significance in detecting liver cirrhosis compared to liver biopsy in chronic liver disease patients. This procedure may help in reducing the risk associated with invasive liver biopsy. Future studies are needed to evaluate transient elastography accuracy in detecting other fibrosis stages such as F2 and F3 compared to liver biopsy.

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Not assigned.





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