Single-molecule labeling for studying trafficking of renal transporters

Document Type

Article

Publication Date

11-1-2018

Publication Title

American journal of physiology. Renal physiology

Abstract

The ability to detect and track single molecules presents the advantage of visualizing the complex behavior of transmembrane proteins with a time and space resolution that would otherwise be lost with traditional labeling and biochemical techniques. Development of new imaging probes has provided a robust method to study their trafficking and surface dynamics. This mini-review focuses on the current technology available for single-molecule labeling of transmembrane proteins, their advantages, and limitations. We also discuss the application of these techniques to the study of renal transporter trafficking in light of recent research.

PubMed ID

30043625

Volume

315

Issue

5

First Page

1243

Last Page

1243

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