Title
Single-molecule labeling for studying trafficking of renal transporters
Recommended Citation
Jaykumar AB, Caceres PS, Ortiz PA. Mini review: Single molecule labeling for studying trafficking of renal transporters. Am J Physiol Renal Physiol. 2018;315(5):F1243-F1249.
Document Type
Article
Publication Date
11-1-2018
Publication Title
American journal of physiology. Renal physiology
Abstract
The ability to detect and track single molecules presents the advantage of visualizing the complex behavior of transmembrane proteins with a time and space resolution that would otherwise be lost with traditional labeling and biochemical techniques. Development of new imaging probes has provided a robust method to study their trafficking and surface dynamics. This mini-review focuses on the current technology available for single-molecule labeling of transmembrane proteins, their advantages, and limitations. We also discuss the application of these techniques to the study of renal transporter trafficking in light of recent research.
PubMed ID
30043625
Volume
315
Issue
5
First Page
1243
Last Page
1243
