The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

Document Type

Article

Publication Date

5-1-2017

Publication Title

Ageing research reviews

Abstract

Because cardiovascular disease remains the major cause of mortality and morbidity world-wide, there remains a compelling need for new insights and novel therapeutic avenues. In this regard, the senescence-accelerated mouse prone 8 (SAMP8) line is a particularly good model for studying the effects of aging on cardiovascular health. Accumulating evidence suggests that this model may shed light on age-associated cardiac and vascular dysfunction and disease. These animals manifest evidence of inflammation, oxidative stress and adverse cardiac remodeling that may recapitulate processes involved in human disease. Early alterations in oxidative damage promote endoplasmic reticulum stress to trigger apoptosis and cytokine production in this genetically susceptible mouse strain. Conversely, pharmacological treatments that reduce inflammation and oxidative stress improve cardiac function in these animals. Therefore, the SAMP8 mouse model provides an exciting opportunity to expand our knowledge of aging in cardiovascular disease and the potential identification of novel targets of treatment. Herein, we review the previous studies performed in SAMP8 mice that provide insight into age-related cardiovascular alterations.

Medical Subject Headings

Aging, Premature; Animals; Apoptosis; Cardiovascular System; Cellular Senescence; Disease Models, Animal; Inflammation; Mice; Oxidative Stress

PubMed ID

27825897

Volume

35

First Page

291

Last Page

296

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