Title

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity.

Document Type

Article

Publication Date

1-1-2016

Publication Title

PLoS One

Abstract

Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that hyperglycemia-mediated decrease in ALDH2 activity may impair mitochondrial respiration and ultimately result in cardiac damage. A single dose (65 mg/kg; i.p.) streptozotocin injection to rats resulted in hyperglycemia with blood glucose levels of 443 ± 9 mg/dl versus 121 ± 7 mg/dl in control animals, p

Medical Subject Headings

Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiomegaly; Chronic Disease; Diabetes Mellitus, Experimental; Hyperglycemia; Male; Mitochondria; Myocardium; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley

PubMed ID

27736868

Volume

11

Issue

10

First Page

0163158

Last Page

0163158

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