Title
Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity
Recommended Citation
Mali VR, Pan G, Deshpande M, Thandavarayan RA, Xu J, Yang XP, Palaniyandi SS. Cardiac mitochondrial respiratory dysfunction and tissue damage in chronic hyperglycemia correlate with reduced aldehyde dehydrogenase-2 activity. PLoS One. 2016;11(10):e0163158.
Document Type
Article
Publication Date
1-1-2016
Publication Title
PLoS One
Abstract
Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that hyperglycemia-mediated decrease in ALDH2 activity may impair mitochondrial respiration and ultimately result in cardiac damage. A single dose (65 mg/kg; i.p.) streptozotocin injection to rats resulted in hyperglycemia with blood glucose levels of 443 ± 9 mg/dl versus 121 ± 7 mg/dl in control animals, p
Medical Subject Headings
Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiomegaly; Chronic Disease; Diabetes Mellitus, Experimental; Hyperglycemia; Male; Mitochondria; Myocardium; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley
PubMed ID
27736868
Volume
11
Issue
10
First Page
0163158
Last Page
0163158
