Title

Reversal of Direct Oral Anticoagulants: Guidance from the Anticoagulation Forum.

Document Type

Article

Publication Date

3-27-2019

Publication Title

American journal of hematology

Abstract

Two specific reversal agents for direct oral anticoagulants (DOACs) have been approved in the United States: idarucizumab for dabigatran reversal and andexanet alfa for apixaban and rivaroxaban reversal. Non-specific prohemostatic agents such as prothrombin complex concentrate (PCC) and activated PCC have also been used for DOAC reversal. The goal of this document is to provide comprehensive guidance from the Anticoagulation Forum, a North American organization of anticoagulation providers, regarding use of DOAC reversal agents. We discuss indications for reversal, provide guidance on how the individual reversal agents should be administered, and offer suggestions for stewardship at the health system level. This article is protected by copyright. All rights reserved.

PubMed ID

30916798

ePublication

ePub ahead of print

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