Cardiotoxicities of Novel Therapies in Hematological Malignancies: Monoclonal Antibodies and Enzyme Inhibitors
Recommended Citation
Prathivadhi-Bhayankaram S, Abbasi MA, Ismayl M, Marar RI, Al-Abcha A, El-Am E, Ahmad A, Acevedo AD, Ellauzi R, Villarraga H, Paludo J, and Anavekar N. Cardiotoxicities of Novel Therapies in Hematological Malignancies: Monoclonal Antibodies and Enzyme Inhibitors. Curr Probl Cardiol 2023; 101757.
Document Type
Article
Publication Date
4-23-2023
Publication Title
Current problems in cardiology
Abstract
Monoclonal antibodies (mAB) selectively target leukemia surface antigens and work by either blocking cell surface receptors or triggering the target cell's destruction. Similarly, enzyme inhibitors bind to complex molecular platforms and induce downstream mechanisms that trigger cell death. These are used in a variety of hematologic malignancies. Yet, they also elicit severe immune-mediated reactions as biological agents that require careful monitoring. Cardiovascular effects include cardiomyopathy, ventricular dysfunction, cardiac arrest, and acute coronary syndrome. While there have been scattered reviews of mAB and enzyme inhibitors, a consolidated resource regarding their cardiovascular risk profile is lacking. We provide general recommendations for initial screening and serial monitoring based on the literature.
PubMed ID
37094764
ePublication
ePub ahead of print
Volume
48
Issue
8
First Page
101757
Last Page
101757
