ASSOCIATION BETWEEN BASELINE CARDIOVASCULAR RISK AND SLEEP DURATION IN AMBULATORY US ADULTS: INSIGHTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY
Gupta K, Nagalli S, Kalra R, Zhou W, Gupta R, Prabhu S, and Bajaj N. ASSOCIATION BETWEEN BASELINE CARDIOVASCULAR RISK AND SLEEP DURATION IN AMBULATORY US ADULTS: INSIGHTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY. Journal of the American College of Cardiology 2021; 77(18):10.
Journal of the American College of Cardiology
Background: Baseline CV risk may partially explain the significant variability in sleep duration across a population. We evaluated the association between baseline CV risk and self-reported sleep duration.
Methods: We used data from National Health and Nutrition Examination Survey (NHANES) 2005-2010 and linked cause of death from National Center for Health Statistics for adults aged ≥18 years. The 10-year atherosclerotic CV disease risk score (ASCVD) was used to assess baseline CV risk and self-reported sleep duration was the outcome. We excluded participants with prevalent CV disease, defined as self-reported coronary artery disease, heart failure or stroke. Continuous variables were represented as medians with interquartile range (IQR). Non-linearity was accounted for using restricted cubic spline models.
Results: There were 14,079 eligible participants. Mean age was 46±19 years with 52% women and 46% non-Hispanic Whites. The median 10-year ASCVD risk was 3.5% (0.5, 14.4). There was a U-shaped relationship with 10-year ASCVD risk score and the sleep duration such that participants with a sleep-duration of 6-7 hours had the lowest risk (P-trend<0.001, Figure). The median 10-year ASCVD risk among participants with <6, 6-7 and >7 hours of sleep were 4.6% (0.9, 15.7), 3.3% (0.6, 12.3) and 3.3% (0.4, 17.3), respectively.
Conclusion: Least 10-year ASCVD risk is associated with a self-reported sleep duration of 6-7 hours in ambulatory US adults without prevalent CV disease.