Morbidity of Clostridioides difficile in Necrotizing Pancreatitis: Insights from National Data
Recommended Citation
Jaan A, Dhawan A, Chaudhary AJ, Hafeez N, Nepal M, Sheikh LF, McFarland M, Dunnigan K. Morbidity of Clostridioides difficile in Necrotizing Pancreatitis: Insights from National Data. Am J Gastroenterol 2024; 119(10):S39-S40.
Document Type
Conference Proceeding
Publication Date
10-1-2024
Publication Title
Am J Gastroenterol
Abstract
Introduction: Necrotizing pancreatitis (NP) is a severe and life-threatening form of acute pancreatitis and is frequently associated with organ dysfunction, necessitating intensive care management. The presence of Clostridioides difficile infection (CDI), a common nosocomial infection, can further complicate the clinical course of NP by exacerbating gastrointestinal symptoms and increasing the risk of sepsis. This study aims to analyze the prevalence and outcomes in NP patients with a concurrent CDI. Methods: Using the National Readmission Database 2016-2020, we employed the International Classification of Diseases, 10th revision, Clinical Modifications (ICD-10-CM) codes to identify adult patients (age >18 years) admitted with NP. We further stratified NP hospitalizations based on the presence of CDI. Utilizing a multivariate regression model, we compared the outcomes of NP in patients with CDI. STATA 14.2 was utilized for statistical analysis. Results: We included 68,839 NP patients, of whom 1,217 (1.77%) had CDI. Adjusted analysis showed significantly higher odds of mortality (adjusted odds ratio [aOR]:2.99, P< 0.001), septic shock (aOR:4.94, P< 0.01), acute kidney injury requiring dialysis (AKId) (aOR:2.31, P< 0.001) and ICU admission (aOR:3.53, P< 0.001) in NP patients with CDI (Table 1). Pancreatitis-specific complications such as pancreatic pseudocyst, portal vein thrombosis, and infection of necrosis requiring necrosectomy were also higher in patients with a CDI. Moreover, NP patients with CDI also had higher odds of developing abdominal compartment syndrome, a rare life-threatening complication. Conclusion: The presence of CDI in patients with NP is associated with higher rates of pancreatitis-specific complications and significantly worse hospitalization outcomes. These findings underscore the importance of vigilant monitoring and proactive management of CDI in NP patients to improve outcomes and reduce the healthcare burden. (Table Presented).
Volume
119
Issue
10
First Page
S39
Last Page
S40
