PAI-1 gain of function genotype and airway obstruction in asthma.

Authors

M G. Sherenian
S H. Cho
Albert M. Levin, Henry Ford HealthFollow
J Y. Min
S Sen
S Oh
S Huntsman
C Eng
H J. Farber
W Rodriguez-Cintron
J R. Rodriguez-Santana
D Serebrisky
L Borrell
Keoki L. Williams, Henry Ford HealthFollow
S Thyne
M S. Seibold
E Burchard
R Kumar

Recommended Citation

Sherenian MG, Cho SH, Levin AM, Min JY, Sen S, Oh S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Borrell L, Williams LK, Thyne S, Seibold MA, Burchard E, and Kumar R. PAI-1 gain of function genotype and airway obstruction in asthma. J Allergy Clin Immunol 2017; 139(2):AB171.

Document Type

Conference Proceeding

Publication Date

2017

Publication Title

J Allergy Clin Immunol

Abstract

RATIONALE: A gain of function promoter polymorphism in Plasminogen Activator Inhibitor -1 (PAI-1) modulates airway remodeling. We sought to determine if this polymorphism is associated with greater airway obstruction in children with asthma. METHODS: We studied 2070 Latino children (8-21y) from the GALA II cohort with genotypic and pulmonary function data. The rs2227631 snp was categorized as wild-type (AA) or any risk allele (AG, GG). We examined the association of the polymorphism with asthma and airway obstruction within asthmatics (FEV1/FVC

Volume

139

Issue

2

First Page

AB171