Calcineurin Inhibitors and Neutropenia: Is Cyclosporine Superior to Tacrolimus?
Duggal T, Dempster M, and Prashar R. Calcineurin Inhibitors and Neutropenia: Is Cyclosporine Superior to Tacrolimus? Am J Case Rep 2019; 20:1407-1410.
Am J Case Rep
BACKGROUND Renal Transplant recipients are at risk for developing neutropenia from a multitude of causes. The cause is often multifactorial, and reversal of the most common causes/insults is sometimes insufficient. CASE REPORT We present the case of a renal transplant recipient who developed a prolonged course of post-transplant (PTx) neutropenia that resolved after switching from tacrolimus (tac) to cyclosporine (CsA). CONCLUSIONS Transplant recipients with persistent neutropenia, sometimes despite discontinuation of potential myelosuppressive agents like mycophenolic acid (MPA), valganciclovir, and sulfamethoxazole-trimethoprim (SMZ-TMP), and with introduction of granulocyte colony-stimulating factor (G-SF), and ruling out alternative diagnoses, may benefit from changing from tac to CsA.