Title

Sodium-Based Osmotherapy in Continuous Renal Replacement Therapy: a Mathematical Approach

Document Type

Article

Publication Date

4-2020

Publication Title

Kidney 360

Abstract

Cerebral edema, in a variety of circumstances, may be accompanied by states of hyponatremia. The threat of brain injury from hypotonic stress-induced astrocyte demyelination is more common when vulnerable patients with hyponatremia who have end stage liver disease, traumatic brain injury, heart failure, or other conditions undergo overly rapid correction of hyponatremia. These scenarios, in the context of declining urinary output from CKD and/or AKI, may require controlled elevations of plasma tonicity vis-à-vis increases of the plasma sodium concentration. We offer a strategic solution to this problem via sodium-based osmotherapy applied through a conventional continuous RRT modality: predilution continuous venovenous hemofiltration.

PubMed ID

Not assigned.

Volume

1

Issue

4

First Page

281

Last Page

291

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